Oxford Scientists Working on Vaccine to Prevent Cancer in People with Genetic Disorder

Oxford Scientists Aim to Develop Vaccine for Genetic Cancer Risk Disorder

September 10, 2024

Researchers at the University of Oxford are embarking on an innovative project to develop a vaccine for Lynch syndrome, a genetic condition that significantly increases the risk of various cancers. Known as LynchVax, the initiative targets individuals with this condition who are predisposed to cancers such as bowel, womb, and ovarian cancer due to a mutation in their DNA repair genes.

Lynch syndrome affects approximately one in 400 people in England, with only 5% of those affected being aware of their condition. Each year, it contributes to around 1,100 bowel cancer cases in England, elevating the lifetime risk of developing the disease by up to 80%.

The research team aims to create a vaccine that could potentially train the immune system to identify and destroy pre-cancerous cells, thereby preventing the onset of cancer. By analyzing cells from Lynch syndrome patients that are showing early signs of cancer, scientists will identify potential targets for the vaccine and evaluate its effectiveness.

Professor Simon Leedham, a leading researcher in the project, highlights the significant potential of LynchVax: “While our work is in its early stages, we are hopeful that this vaccine could significantly reduce the risk of multiple cancers in those with Lynch syndrome, potentially improving survival rates.”

The initiative is supported by a £550,000 grant from Cancer Research UK. Michelle Mitchell, Chief Executive of Cancer Research UK, underscores the importance of such projects: “Cancer vaccines are a promising frontier in cancer prevention, and LynchVax represents a crucial step towards a future where cancers linked to Lynch syndrome could be prevented.”

For more details, you can read the full article on BBC Oxfordshire.

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